MCA stability tool

Check whether tablets and capsules are suitable for a multi-compartment compliance aid (MCA), and build a list to print.

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Medicines beginning with C

Co-beneldopa

Co-beneldopa 12.5mg/50mg capsules

Incompatible

Stability notes for Co-beneldopa 12.5mg/50mg capsules

Very moisture sensitive medicine. Original packaging may contain desiccant. Manufacturer recommends storing in original container. Complex administration instruction. Mixed results from stability studies. Visual degradation observed in sealed MCAs at high humidity. Levodopa is known to lose potency with exposure to moisture.

Provenance

This recommendation is based on the products Madopar 12.5mg/50mg capsules (Roche Products Limited) and co-beneldopa 12.5mg/50mg capsules (Teva UK Limited).

Suppliers (5) of Co-beneldopa 12.5mg/50mg capsules
Co-beneldopa 12.5mg/50mg capsules (A A H Pharmaceuticals Ltd)
Co-beneldopa 12.5mg/50mg capsules (Alliance Healthcare (Distribution) Ltd)
Co-beneldopa 12.5mg/50mg capsules (Medihealth (Northern) Ltd)
Co-beneldopa 12.5mg/50mg capsules (Teva UK Ltd)
Madopar 50mg/12.5mg capsules (Roche Products Ltd)

Co-beneldopa 12.5mg/50mg dispersible tablets sugar free

Incompatible

Stability notes for Co-beneldopa 12.5mg/50mg dispersible tablets sugar free

Very moisture sensitive medicine. Original packaging may contain desiccant. Manufacturer recommends storing in original container. Complex administration instruction. Tablet darkening indicates loss of potency due to moisture. Mixed results from stability studies. Visual degradation observed in sealed MCAs at high humidity.

Provenance

This recommendation is based on the product Madopar 12.5mg/50mg dispersible tablets (Roche Products Limited)

Supplier

Madopar 50mg/12.5mg dispersible tablets (Roche Products Ltd)

Co-beneldopa 25mg/100mg capsules

Incompatible

Stability notes for Co-beneldopa 25mg/100mg capsules

Very moisture sensitive medicine. Original packaging may contain desiccant. Manufacturer recommends storing in original container. Complex administration instruction. Mixed results from stability studies. Visual degradation observed in sealed MCAs at high humidity. Levodopa is known to lose potency with exposure to moisture.

Provenance

This recommendation is based on the products Madopar 25mg/100mg capsules (Roche Products Limited) and co-beneldopa 25mg/100mg capsules (Teva UK Limited).

Supplier

Madopar 100mg/25mg capsules (Roche Products Ltd)

Co-beneldopa 25mg/100mg dispersible tablets sugar free

Incompatible

Stability notes for Co-beneldopa 25mg/100mg dispersible tablets sugar free

Very moisture sensitive medicine. Original packaging may contain desiccant. Manufacturer recommends storing in original container. Complex administration instruction. Tablet darkening indicates loss of potency due to moisture. Mixed results from stability studies. Visual degradation observed in sealed MCAs at high humidity.

Provenance

This recommendation is based on the product Madopar 25mg/100mg dispersible tablets (Roche Products Limited).

Suppliers

Madopar 100mg/25mg dispersible tablets (Necessity Supplies Ltd)
Madopar 100mg/25mg dispersible tablets (Roche Products Ltd)
Madopar 100mg/25mg dispersible tablets (Sigma Pharmaceuticals Plc)

Co-beneldopa 25mg/100mg modified-release capsules

Incompatible

Stability notes for Co-beneldopa 25mg/100mg modified-release capsules

Very moisture sensitive medicine. Original packaging may contain desiccant. Manufacturer recommends storing in original container. Complex administration instruction. Mixed results from stability studies. Visual degradation observed in sealed MCAs at high humidity.
Levodopa is known to lose potency with exposure to moisture.

Provenance

This recommendation is based on the products Madopar 25mg/100mg modified release capsules (Roche Products Limited)

Suppliers

Madopar CR capsules (Roche Products Ltd)
Madopar CR capsules (Sigma Pharmaceuticals Plc)

Co-beneldopa 50mg/200mg capsules

Incompatible

Stability notes for Co-beneldopa 50mg/200mg capsules

Very moisture sensitive medicine. Original packaging may contain desiccant. Manufacturer recommends storing in original container. Complex administration instruction. Mixed results from stability studies. Visual degradation observed in sealed MCAs at high humidity. Levodopa is known to lose potency with exposure to moisture.

Provenance

This recommendation is based on the products Madopar 50mg/200mg capsules (Roche Products Limited).

Supplier

Madopar 200mg/50mg capsules (Roche Products Ltd)

What the ratings mean

Compatible
Suitable for use. Keep in MCA for shortest possible time: no more than 5 weeks for non-airtight; 8 weeks for airtight. Use likely to be off-label.
Use with caution
Suitable with mitigations. Keep in MCA for shortest possible time: no more than 5 weeks for non-airtight; 8 weeks for airtight. Use likely to be off-label and supported by limited data.
Incompatible
Medicines under this category are not suitable for use in MCAs.
No stability information
These medicines have not been reviewed by SPS.